Prevalence and clinical characteristics of human metapneumovirus infections in hospitalized infants in Spain.
Identifieur interne : 000597 ( Main/Exploration ); précédent : 000596; suivant : 000598Prevalence and clinical characteristics of human metapneumovirus infections in hospitalized infants in Spain.
Auteurs : M L García-García [Espagne] ; C. Calvo ; P. Pérez-Bre A ; J M De Cea ; B. Acosta ; I. CasasSource :
- Pediatric pulmonology [ 8755-6863 ] ; 2006.
Descripteurs français
- KwdFr :
- MESH :
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- MESH :
- geographic : Spain.
- epidemiology : Paramyxoviridae Infections, Respiratory Syncytial Virus Infections.
- Female, Hospitalization, Humans, Infant, Male, Metapneumovirus, Prevalence, Prospective Studies.
Abstract
Human metapneumovirus (hMPV), a condition recently described in the Netherlands, causes lower respiratory infections, particularly in young children and among the elderly. The objective of this study was to describe the characteristics of hMPV infections in hospitalized infants <2 years of age and to compare them to those of infections caused by respiratory syncytial virus (RSV). A prospective study was conducted on the clinical characteristics of infants admitted to hospital for respiratory infection through 5 years. Simultaneous detection of influenza A, B, and C viruses, RSV, and adenoviruses was performed in clinical samples by multiple reverse transcription nested-PCR assay. The presence of hMPV was tested in all samples using two separate RT-PCR tests. Some respiratory virus was detected in 70.5% of the 1,322 children included in the study. hMPV was found in 101 of the positive nasopharyngeal aspirates (10.8%), and was the most common virus after RSV and rhinovirus. Peak incidence was found in March. Over 80% of children were <12 months. The more common diagnoses were bronchiolitis (49.5%) and recurrent wheezing (45.5%). Fifty-four percent of cases required oxygen therapy and, one percent, assisted ventilation. Thirty percent were co-infections, with clinical characteristics indistinguishable from single infections. Seventy-one hMPV single infections were compared to 88 RSV single infections. hMPV infections were significantly more frequent than RSV in infants older than 6 months (P = 0.04). Recurrent wheezing was diagnosed more frequently in hMPV patients (P = 0.001). All other variables tested were similar, in both groups. hMPV was the third most frequent virus after RSV and rhinovirus in infants <2 years of age, hospitalized for respiratory infection, and was associated with bronchiolitis and recurrent wheezing. hMPV predominantly occurred in spring. Co-infections were frequent and clinically similar to single infections and RSV infections.
DOI: 10.1002/ppul.20456
PubMed: 16850437
PubMed Central: PMC7167809
Affiliations:
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Pérez-Bre A</name></author><author><name sortKey="De Cea, J M" sort="De Cea, J M" uniqKey="De Cea J" first="J M" last="De Cea">J M De Cea</name></author><author><name sortKey="Acosta, B" sort="Acosta, B" uniqKey="Acosta B" first="B" last="Acosta">B. Acosta</name></author><author><name sortKey="Casas, I" sort="Casas, I" uniqKey="Casas I" first="I" last="Casas">I. 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Calvo</name></author><author><name sortKey="Perez Bre A, P" sort="Perez Bre A, P" uniqKey="Perez Bre A P" first="P" last="Pérez-Bre A">P. Pérez-Bre A</name></author><author><name sortKey="De Cea, J M" sort="De Cea, J M" uniqKey="De Cea J" first="J M" last="De Cea">J M De Cea</name></author><author><name sortKey="Acosta, B" sort="Acosta, B" uniqKey="Acosta B" first="B" last="Acosta">B. Acosta</name></author><author><name sortKey="Casas, I" sort="Casas, I" uniqKey="Casas I" first="I" last="Casas">I. Casas</name></author></analytic><series><title level="j">Pediatric pulmonology</title><idno type="ISSN">8755-6863</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Female (MeSH)</term><term>Hospitalization (MeSH)</term><term>Humans (MeSH)</term><term>Infant (MeSH)</term><term>Male (MeSH)</term><term>Metapneumovirus (MeSH)</term><term>Paramyxoviridae Infections (epidemiology)</term><term>Prevalence (MeSH)</term><term>Prospective Studies (MeSH)</term><term>Respiratory Syncytial Virus Infections (epidemiology)</term><term>Spain (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Espagne (MeSH)</term><term>Femelle (MeSH)</term><term>Hospitalisation (MeSH)</term><term>Humains (MeSH)</term><term>Infections à Paramyxoviridae (épidémiologie)</term><term>Infections à virus respiratoire syncytial (épidémiologie)</term><term>Metapneumovirus (MeSH)</term><term>Mâle (MeSH)</term><term>Nourrisson (MeSH)</term><term>Prévalence (MeSH)</term><term>Études prospectives (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Paramyxoviridae Infections</term><term>Respiratory Syncytial Virus Infections</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à Paramyxoviridae</term><term>Infections à virus respiratoire syncytial</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Hospitalization</term><term>Humans</term><term>Infant</term><term>Male</term><term>Metapneumovirus</term><term>Prevalence</term><term>Prospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Espagne</term><term>Femelle</term><term>Hospitalisation</term><term>Humains</term><term>Metapneumovirus</term><term>Mâle</term><term>Nourrisson</term><term>Prévalence</term><term>Études prospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Human metapneumovirus (hMPV), a condition recently described in the Netherlands, causes lower respiratory infections, particularly in young children and among the elderly. The objective of this study was to describe the characteristics of hMPV infections in hospitalized infants <2 years of age and to compare them to those of infections caused by respiratory syncytial virus (RSV). A prospective study was conducted on the clinical characteristics of infants admitted to hospital for respiratory infection through 5 years. Simultaneous detection of influenza A, B, and C viruses, RSV, and adenoviruses was performed in clinical samples by multiple reverse transcription nested-PCR assay. The presence of hMPV was tested in all samples using two separate RT-PCR tests. Some respiratory virus was detected in 70.5% of the 1,322 children included in the study. hMPV was found in 101 of the positive nasopharyngeal aspirates (10.8%), and was the most common virus after RSV and rhinovirus. Peak incidence was found in March. Over 80% of children were <12 months. The more common diagnoses were bronchiolitis (49.5%) and recurrent wheezing (45.5%). Fifty-four percent of cases required oxygen therapy and, one percent, assisted ventilation. Thirty percent were co-infections, with clinical characteristics indistinguishable from single infections. Seventy-one hMPV single infections were compared to 88 RSV single infections. hMPV infections were significantly more frequent than RSV in infants older than 6 months (P = 0.04). Recurrent wheezing was diagnosed more frequently in hMPV patients (P = 0.001). All other variables tested were similar, in both groups. hMPV was the third most frequent virus after RSV and rhinovirus in infants <2 years of age, hospitalized for respiratory infection, and was associated with bronchiolitis and recurrent wheezing. hMPV predominantly occurred in spring. Co-infections were frequent and clinically similar to single infections and RSV infections.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16850437</PMID><DateCompleted><Year>2007</Year><Month>03</Month><Day>29</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>22</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">8755-6863</ISSN><JournalIssue CitedMedium="Print"><Volume>41</Volume><Issue>9</Issue><PubDate><Year>2006</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Pediatric pulmonology</Title><ISOAbbreviation>Pediatr. Pulmonol.</ISOAbbreviation></Journal><ArticleTitle>Prevalence and clinical characteristics of human metapneumovirus infections in hospitalized infants in Spain.</ArticleTitle><Pagination><MedlinePgn>863-71</MedlinePgn></Pagination><Abstract><AbstractText>Human metapneumovirus (hMPV), a condition recently described in the Netherlands, causes lower respiratory infections, particularly in young children and among the elderly. The objective of this study was to describe the characteristics of hMPV infections in hospitalized infants <2 years of age and to compare them to those of infections caused by respiratory syncytial virus (RSV). A prospective study was conducted on the clinical characteristics of infants admitted to hospital for respiratory infection through 5 years. Simultaneous detection of influenza A, B, and C viruses, RSV, and adenoviruses was performed in clinical samples by multiple reverse transcription nested-PCR assay. The presence of hMPV was tested in all samples using two separate RT-PCR tests. Some respiratory virus was detected in 70.5% of the 1,322 children included in the study. hMPV was found in 101 of the positive nasopharyngeal aspirates (10.8%), and was the most common virus after RSV and rhinovirus. Peak incidence was found in March. Over 80% of children were <12 months. The more common diagnoses were bronchiolitis (49.5%) and recurrent wheezing (45.5%). Fifty-four percent of cases required oxygen therapy and, one percent, assisted ventilation. Thirty percent were co-infections, with clinical characteristics indistinguishable from single infections. Seventy-one hMPV single infections were compared to 88 RSV single infections. hMPV infections were significantly more frequent than RSV in infants older than 6 months (P = 0.04). Recurrent wheezing was diagnosed more frequently in hMPV patients (P = 0.001). All other variables tested were similar, in both groups. hMPV was the third most frequent virus after RSV and rhinovirus in infants <2 years of age, hospitalized for respiratory infection, and was associated with bronchiolitis and recurrent wheezing. hMPV predominantly occurred in spring. Co-infections were frequent and clinically similar to single infections and RSV infections.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>García-García</LastName><ForeName>M L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, Severo Ochoa Hospital, Madrid, Spain. marialuzgarcia@terra.es</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Calvo</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Pérez-Breña</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>De Cea</LastName><ForeName>J M</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Acosta</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Casas</LastName><ForeName>I</ForeName><Initials>I</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Pediatr Pulmonol</MedlineTA><NlmUniqueID>8510590</NlmUniqueID><ISSNLinking>1099-0496</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Pediatr Pulmonol. 2007 Jan;42(1):98; athor reply 99</RefSource><PMID Version="1">17133527</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="Y">Hospitalization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" 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Acosta</name><name sortKey="Calvo, C" sort="Calvo, C" uniqKey="Calvo C" first="C" last="Calvo">C. Calvo</name><name sortKey="Casas, I" sort="Casas, I" uniqKey="Casas I" first="I" last="Casas">I. Casas</name><name sortKey="De Cea, J M" sort="De Cea, J M" uniqKey="De Cea J" first="J M" last="De Cea">J M De Cea</name><name sortKey="Perez Bre A, P" sort="Perez Bre A, P" uniqKey="Perez Bre A P" first="P" last="Pérez-Bre A">P. Pérez-Bre A</name></noCountry><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Garcia Garcia, M L" sort="Garcia Garcia, M L" uniqKey="Garcia Garcia M" first="M L" last="García-García">M L García-García</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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